Differentiating recurrent or residual nasopharyngeal carcinomas from post-radiotherapy changes with 18-fluoro-2deoxyglucose positron emission tomography and thallium-201 single photon emission computed tomography in patients with indeterminate computed tomography findings

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Title:	Differentiating recurrent or residual nasopharyngeal carcinomas from post-radiotherapy changes with 18-fluoro-2deoxyglucose positron emission tomography and thallium-201 single photon emission computed tomography in patients with indeterminate computed tomography findings
Authors:	Tsai, MH;Huang, WS;Tsai, JJP;Chen, YK;Changlai, SP;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Univ Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Univ Hosp, PET Ctr, Taichung 404, Taiwan;China Med Univ Hosp, PET Ctr, Taichung, Taiwan;China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan;China Med Univ Hosp, Dept Otolaryngol, Taichung, Taiwan;Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Nucl Med, Taipei, Taiwan;Tri Serv Gen Hosp, Natl Def Med Ctr, PET Ctr, Taipei, Taiwan;Taichung Healthcare & Management Univ, Grad Inst Bioinformat, Taichung, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, PET Ctr, Taipei, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:40:23 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	The effects of Saikosaponin-A on human breast cancer cell lines (MDA-MB-231 and MCF-7) were investigated. Results demonstrated that Saikosaponin-A inhibited the proliferation or viability of the MDA-MB-231 and MCF-7 cells in a dose-dependent manner. Saikosaponin-A treatment of MDA-MB-231 for 3 hours and of MCF-7 cells for 2 hours, respectively caused an obvious increase in the sub-G I population of cell cycles. Apoptosis in MDA-MB-231 cells was independent of the P53/p21 pathway mechanism and was accompanied by an increased ratio of Bax to Bcl-2 and c-myc levels and activation of caspase-3. In contrast, apoptosis of MCF-7 cells may have been initiated by the Bcl-2 family of proteins and involved p53/p21 dependent pathway mechanism, and was accompanied by an increased level of cmyc protein. Both the apoptosis of MDA-MB-231 cells and MCF-7 cells showed a difference worthy of further research.
Relation:	ANTICANCER RESEARCH 23(4):3513-3516
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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