Thrombomodulin-mediated cell adhesion - Involvement of its lectin-like domain

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Title:	Thrombomodulin-mediated cell adhesion - Involvement of its lectin-like domain
Authors:	Huang, HC;Shi, GY;Jiang, SJ;Shi, CS;Wu, CM;Yang, HY;Wu, HL
Contributors:	健康照護學院醫技系;Natl Cheng Kung Univ, Coll Med, Dept Biochem, Tainan 701, Taiwan;Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 701, Taiwan;China Med Coll, Dept Med Technol, Taichung 404, Taiwan;Natl Taiwan Univ, Inst Mol & Cell Biol, Taipei 107, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:38:26 (UTC+8)
Publisher:	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Abstract:	The multidrug resistance gene 1 encoding human P-glycoprotein (Pgp) is thought to play an important role in the multidrug resistance of lung cancer. The purpose of this study was to predict chemotherapy response by technetium-99m tetrofosmin (Tc-99m TF) lung single photon emission computed tomography (SPECT) and compare Pgp expression in patients with untreated small cell lung cancer (SCLC). Forty patients with untreated SCLC received Tc-99m TF lung SPECT prior to chemotherapy. The chemotherapy response was evaluated in the 3rd month after completion of treatment. Immunohistochemical staining of Pgp expression was performed on multiple nonconsecutive sections of biopsy specimens. By quantitative analyses, tumor to background ratios were 1.86+/-0.27 and 1.17+/-0.26 for patients with a good and poor response, respectively (p<0.05). All of the 20 patients with a good chemotherapy response also had a positive Tc-99m TF lung SPECT and negative Pgp expression. In contrast, only 4 of the 20 patients with a poor chemotherapy response had a positive Tc-99m TF lung SPECT. Moreover, 10 of the 20 patients with a poor chemotherapy response also had negative Pgp expression (p<0.05). Therefore, we concluded that Tc-99m TF lung SPECT can accurately predict the chemotherapy response, and Tc-99m TF lung SPECT findings can be partially compatible with Pgp expression in patients with untreated SCLC. Copyright (C) 2003 S. Karger AG, Basel.
Relation:	JOURNAL OF BIOLOGICAL CHEMISTRY 278(47):46750-46759
Appears in Collections:	[Department of Medical Laboratory Science and Biotechnology ] Journal articles

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