Thrombomodulin-mediated cell adhesion - Involvement of its lectin-like domain

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/29589

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題名:	Thrombomodulin-mediated cell adhesion - Involvement of its lectin-like domain
作者:	Huang, HC;Shi, GY;Jiang, SJ;Shi, CS;Wu, CM;Yang, HY;Wu, HL
貢獻者:	健康照護學院醫技系;Natl Cheng Kung Univ, Coll Med, Dept Biochem, Tainan 701, Taiwan;Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 701, Taiwan;China Med Coll, Dept Med Technol, Taichung 404, Taiwan;Natl Taiwan Univ, Inst Mol & Cell Biol, Taipei 107, Taiwan
日期:	2003
上傳時間:	2010-09-24 14:38:26 (UTC+8)
出版者:	AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
摘要:	The multidrug resistance gene 1 encoding human P-glycoprotein (Pgp) is thought to play an important role in the multidrug resistance of lung cancer. The purpose of this study was to predict chemotherapy response by technetium-99m tetrofosmin (Tc-99m TF) lung single photon emission computed tomography (SPECT) and compare Pgp expression in patients with untreated small cell lung cancer (SCLC). Forty patients with untreated SCLC received Tc-99m TF lung SPECT prior to chemotherapy. The chemotherapy response was evaluated in the 3rd month after completion of treatment. Immunohistochemical staining of Pgp expression was performed on multiple nonconsecutive sections of biopsy specimens. By quantitative analyses, tumor to background ratios were 1.86+/-0.27 and 1.17+/-0.26 for patients with a good and poor response, respectively (p<0.05). All of the 20 patients with a good chemotherapy response also had a positive Tc-99m TF lung SPECT and negative Pgp expression. In contrast, only 4 of the 20 patients with a poor chemotherapy response had a positive Tc-99m TF lung SPECT. Moreover, 10 of the 20 patients with a poor chemotherapy response also had negative Pgp expression (p<0.05). Therefore, we concluded that Tc-99m TF lung SPECT can accurately predict the chemotherapy response, and Tc-99m TF lung SPECT findings can be partially compatible with Pgp expression in patients with untreated SCLC. Copyright (C) 2003 S. Karger AG, Basel.
關聯:	JOURNAL OF BIOLOGICAL CHEMISTRY 278(47):46750-46759
顯示於類別:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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