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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29571
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| 題名: | Genetic analysis and clinical evaluation of vacuolating cytotoxin gene A and cytotoxin-associated gene A in Taiwanese Helicobacter pylori isolates from peptic ulcer patients |
| 作者: | Lin, CW;Wu, SC;Lee, SC;Cheng, KS |
| 貢獻者: | 健康照護學院醫技系;China Med Coll, Sch Med Technol, Taichung 404, Taiwan;Natl Tsing Hua Univ, Dept Life Sci, Hsinchu, Taiwan;China Med Coll Hosp, Dept Internal Med, Div Gastroenterol, Taichung, Taiwan |
| 日期: | 2000 |
| 上傳時間: | 2010-09-24 14:38:04 (UTC+8) |
| 出版者: | SCANDINAVIAN UNIVERSITY PRESS |
| 摘要: | OBJECTIVE The CTLA4 (cytotoxic T lymphocyte associated antigen-4) gene encodes the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis. Thus it is a strong candidate gene for T cell-mediated autoimmune disease. There is polymorphism at position 49 in exon 1 of the CTLA4 gene, providing a A-G exchange. This polymorphism is reportedly associated with type 1 diabetes in Caucasians but not in a small data set of Chinese. We wished to test this polymorphism in a larger and more homogeneous data set of Chinese children with type 1 diabetes and normal adult controls. DESIGN A population-based case-control study of a CTLA4 gene 49 A-G polymorphism was performed to look for an association with type 1 diabetes in Chinese children. PATIENTS We analysed this polymorphism in 253 unrelated children (128 boys) with type 1 diabetes (age at diagnosis 7.1 +/- 3.7 years) and 91 randomly selected normal adults. All individuals were Han Chinese. RESULTS The genotype and gene frequencies of children with type 1 diabetes differed significantly from those of adult controls (P = 0.0091 and P = 0.0051, respectively). Genotype CTLA4 49 G/G and G allele conferred a risk of type 1 diabetes (RR = 2.13, 95% CI = 1.31-3.46, P = 0.0022; RR = 1.68, 95% CI = 1.17-2.43, P = 0.0051, respectively). CONCLUSIONS This study demonstrates that CTLA4 49 A-G polymorphism is associated with type 1 diabetes in Han Chinese children. The CTLA4 49 G allele confers an increased risk of type 1 diabetes. |
| 關聯: | SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 32(1):51-57 |
| 顯示於類別: | [醫學檢驗生物技術學系暨碩士班 ] 期刊論文
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