Genetic analysis and clinical evaluation of vacuolating cytotoxin gene A and cytotoxin-associated gene A in Taiwanese Helicobacter pylori isolates from peptic ulcer patients

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Title:	Genetic analysis and clinical evaluation of vacuolating cytotoxin gene A and cytotoxin-associated gene A in Taiwanese Helicobacter pylori isolates from peptic ulcer patients
Authors:	Lin, CW;Wu, SC;Lee, SC;Cheng, KS
Contributors:	健康照護學院醫技系;China Med Coll, Sch Med Technol, Taichung 404, Taiwan;Natl Tsing Hua Univ, Dept Life Sci, Hsinchu, Taiwan;China Med Coll Hosp, Dept Internal Med, Div Gastroenterol, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:38:04 (UTC+8)
Publisher:	SCANDINAVIAN UNIVERSITY PRESS
Abstract:	OBJECTIVE The CTLA4 (cytotoxic T lymphocyte associated antigen-4) gene encodes the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis. Thus it is a strong candidate gene for T cell-mediated autoimmune disease. There is polymorphism at position 49 in exon 1 of the CTLA4 gene, providing a A-G exchange. This polymorphism is reportedly associated with type 1 diabetes in Caucasians but not in a small data set of Chinese. We wished to test this polymorphism in a larger and more homogeneous data set of Chinese children with type 1 diabetes and normal adult controls. DESIGN A population-based case-control study of a CTLA4 gene 49 A-G polymorphism was performed to look for an association with type 1 diabetes in Chinese children. PATIENTS We analysed this polymorphism in 253 unrelated children (128 boys) with type 1 diabetes (age at diagnosis 7.1 +/- 3.7 years) and 91 randomly selected normal adults. All individuals were Han Chinese. RESULTS The genotype and gene frequencies of children with type 1 diabetes differed significantly from those of adult controls (P = 0.0091 and P = 0.0051, respectively). Genotype CTLA4 49 G/G and G allele conferred a risk of type 1 diabetes (RR = 2.13, 95% CI = 1.31-3.46, P = 0.0022; RR = 1.68, 95% CI = 1.17-2.43, P = 0.0051, respectively). CONCLUSIONS This study demonstrates that CTLA4 49 A-G polymorphism is associated with type 1 diabetes in Han Chinese children. The CTLA4 49 G allele confers an increased risk of type 1 diabetes.
Relation:	SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 32(1):51-57
Appears in Collections:	[Department of Medical Laboratory Science and Biotechnology ] Journal articles

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