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http://ir.cmu.edu.tw/ir/handle/310903500/29466
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| 題名: | The role of Tc-99m methoxyisobutylisonitrile scintimammography as compared to mammography in evaluating palpable breast masses of Taiwanese women |
| 作者: | Sun, SS;Hsieh, JF;Tsai, SC;Ho, YJ;Lee, JK;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;Taichung Vet Gen Hosp, Dept Nucl Med, Sect 3, Taichung 407, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;Chi Mei Fdn Hosp, Dept Nucl Med, Tainan, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Changhua, Taiwan;Taipei Municipal Jen Ai Hosp, Dept Radiol, Taichung, Taiwan |
| 日期: | 2000 |
| 上傳時間: | 2010-09-24 14:35:08 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | Berberine is an alkaloid occurring in the plant genera Berberis and Coptis. Although berberine had been demonstrated to have antineoplastic function by inhibiting DNA-synthesis in activated lymphocytes, there is no available information to address berberine affects on human leukemia cell N-acetyltransferase (NAT) activity and 2-aminofluorene (AF)-DNA adduct formation. Thus, berberine was tested for inhibition of arylamine NAT activity and AF-DNA adduct formation in human leukemia cells. The NAT activity was measured by a high performance liquid chromatography assaying for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and the remaining AF and p-aminobenzoic acid (PABA). The NAT activity and AF-DNA adduct formation in human leukemia cells were inhibited by berberine in a dose-dependent manner, i.e. the higher the concentration of berberine, the higher the inhibition of NAT activity and AF-DNA adduct. The data also indicate that berberine decreased the apparent values of Km and Vmax from human leukemia cells in both cytosol acid intact cells. |
| 關聯: | ANTICANCER RESEARCH 20(3B):2133-2136 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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