The role of Tc-99m methoxyisobutylisonitrile scintimammography as compared to mammography in evaluating palpable breast masses of Taiwanese women

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Title:	The role of Tc-99m methoxyisobutylisonitrile scintimammography as compared to mammography in evaluating palpable breast masses of Taiwanese women
Authors:	Sun, SS;Hsieh, JF;Tsai, SC;Ho, YJ;Lee, JK;Kao, CH
Contributors:	附設醫院核子醫學部;Taichung Vet Gen Hosp, Dept Nucl Med, Sect 3, Taichung 407, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;Chi Mei Fdn Hosp, Dept Nucl Med, Tainan, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Changhua, Taiwan;Taipei Municipal Jen Ai Hosp, Dept Radiol, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:35:08 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	Berberine is an alkaloid occurring in the plant genera Berberis and Coptis. Although berberine had been demonstrated to have antineoplastic function by inhibiting DNA-synthesis in activated lymphocytes, there is no available information to address berberine affects on human leukemia cell N-acetyltransferase (NAT) activity and 2-aminofluorene (AF)-DNA adduct formation. Thus, berberine was tested for inhibition of arylamine NAT activity and AF-DNA adduct formation in human leukemia cells. The NAT activity was measured by a high performance liquid chromatography assaying for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and the remaining AF and p-aminobenzoic acid (PABA). The NAT activity and AF-DNA adduct formation in human leukemia cells were inhibited by berberine in a dose-dependent manner, i.e. the higher the concentration of berberine, the higher the inhibition of NAT activity and AF-DNA adduct. The data also indicate that berberine decreased the apparent values of Km and Vmax from human leukemia cells in both cytosol acid intact cells.
Relation:	ANTICANCER RESEARCH 20(3B):2133-2136
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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