 |
English
|
正體中文
|
简体中文
|
全文筆數/總筆數 : 29490/55136 (53%)
造訪人次 : 1496055
線上人數 : 232
|
|
|
資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29423
|
| 題名: | Monitoring bone loss using ELISA and surface plasmon resonance (SPR) technology |
| 作者: | Lung, FDT;Chen, HY;Lin, HT |
| 貢獻者: | 健康照護學院營養系;China Med Coll, Dept Nutr, Taichung 404, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:34:16 (UTC+8) |
| 出版者: | BENTHAM SCIENCE PUBL LTD |
| 摘要: | Background Angiogenesis is an important process in tissue development and wound healing. The Tie-2 receptor tyrosine kinases and ligands, angiopoietin (Ang)-1 and -2 have been postulated to play key roles in vascular development. The purpose of this study was to evaluate the expression of Tie-2 and Ang-1 and -2 in an acetic acid-induced gastric ulcer healing process in rats. Methods. Gastric specimens were obtained at 0 (control), 1, 3, 5, 7, and 14 days after ulcer induction for reverse transcription polymerase chain reaction (RTPCR), Western blot analysis, and immunohistochemical analysis. Results. Expression of Tie-2 and Ang-1 and -2 mRNAs was detected in normal gastric tissue and ulcerative tissues by RT-PCR. Western blot analysis revealed that Tie-2 expression reached a maximum on the third to fifth days. Expression of Ang-1 and -2 peaked on the first day. Ang-1 expression gradually became weaker in 2 weeks, whereas Ang-2 expression returned to normal in a few days. Immunohistochemically, Tie-2 was expressed constitutively in the endothelial cells of pre-existing vessels of the gastric wall, and Tie-2 expression was increased in the new capillaries of the ulcer base. Conclusions. These findings suggest that Tie-2 and Ang-1 and -2 play an important role in angiogenesis in the early phase of ulcer healing. |
| 關聯: | PROTEIN AND PEPTIDE LETTERS 10(3):313-319 |
| 顯示於類別: | [營養學系暨碩士班 ] 期刊論文
|
在CMUR中所有的資料項目都受到原著作權保護.
|
