Overall obesity and abdominal obesity and the risk of metabolic abnormalities

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29363

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题名:	Overall obesity and abdominal obesity and the risk of metabolic abnormalities
作者:	Lai, SW;Ng, KC
贡献者:	附設醫院急診部;China Med Univ Hosp, Dept Emergency Med, Taichung 404, Taiwan;China Med Univ Hosp, Dept Family Med, Taichung, Taiwan
日期:	2004
上传时间:	2010-09-24 14:33:11 (UTC+8)
出版者:	ROYAL ACADEMY MEDICINE
摘要:	The phage-displayed combinatorial peptide library is a revolutionary method for discovering epitopes, in particular conformational epitopes. In this study, we characterized a Japanese encephalitis virus (JEV) conformational epitope by biopanning of phage-displayed random peptide libraries with a JEV envelope (E) protein-specific monoclonal antibody (mAb) 2H2. Eleven identified phage clones with high affinity to mAb 2H2 were identified using direct and inhibitory binding ELISA. Sequence alignment, structure modeling and mutational analysis revealed that the identified mimotopes for mAb 2H2 possess a conserved motif X-1(D/E)(Y/T/S)X-2, fitting into a region at the domain III lateral surface of the E protein. The results of our study could provide useful information on the development of effective mimotope-based vaccines and diagnostic kits for the JEV infection. Copyright (C) 2004 S. Karger AG, Basel.
關聯:	IRISH JOURNAL OF MEDICAL SCIENCE 173(4):193-196
显示于类别:	[台中附設醫院] 期刊論文

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