Ureteral fibroepithelial polyp prolapsed into the bladder cavity suspending a bladder stone

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29336

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题名:	Ureteral fibroepithelial polyp prolapsed into the bladder cavity suspending a bladder stone
作者:	Yeh, CC;Lin, HC;Chen, CC;Wu, HC
贡献者:	附設醫院泌尿部;China Med Coll Hosp, Dept Urol, Taichung, Taiwan
日期:	2001
上传时间:	2010-09-24 14:32:32 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	In this study, we attempted to identify the mechanisms of paeoniflorin on antinociceptive effects in mice. Paeoniflorin (48, 96, 240, 480 mug, i.c.v.) showed dose-related antinociception both on the early and late phases of formalin test in mice. Moreover, paeoniflorin (48 mug, i.c.v.) could potentiate the antinociception of morphrine (0.5, 1.0 mg/kg, s.c.) in the formalin test. However, the antinociceptive effects of paeoniflorin were not potentiated by L-arginine (600 mg/kg, i.p.) or antagonized by beta -funaltrexamine (beta -FNA) (10 mug, i.c.v.), ICI-174,864 (1 mug, i.c.v.) and ryanodine (10 ng, i.c.v.) on both the early and late phases of formalin test. L-NAME (75 mg/kg, i.p.) could reverse the effect of paeoniflorin on the late phase of formalin test. Naloxone (1 mg/kg, i.p.) and nor-binaltorphimine (nor-BNI) (1 mug, i.c.v.) could block the paeoniflorin-induced antinociception on the early phase of formalin test. These results suggested that the central antinociceptive effects of paeoniflorin on formalin test in mice were mediated by the activation of kappa -opioid receptor and not related to the increase of intracellular calcium. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
關聯:	JOURNAL OF UROLOGY 165(5):1627-1628
显示于类别:	[台中附設醫院] 期刊論文

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