INTRACRANIAL FETUS-IN-FETU - CT DIAGNOSIS

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29267

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题名:	INTRACRANIAL FETUS-IN-FETU - CT DIAGNOSIS
作者:	YANG, ST;LEOW, SW
贡献者:	附設醫院放射線部;YANG, ST, CHINA MED COLL HOSP,DEPT RADIOL,75 YUTE RD,TAICHUNG,TAIWAN
日期:	1992
上传时间:	2010-09-24 14:30:01 (UTC+8)
出版者:	AMER SOC NEURORADIOLOGY
摘要:	The pharmacological effects of HA-22 (2-(4'methoxyphenylmethyl)-3,4-dimethylpyrano[2,3-c] pyrazol-6(2H)-one) and HA-23 (2-(2'-thienylmethyl)-3,4-dimethylpyrano[2,3-c]pyrazol-6(2H)-one on rat isolated thoracic aorta have been examined. In high potassium medium (60 mM), Ca2+ (0.03-3 mM)-induced vasoconstriction was inhibited by HA-22 and HA-23 (10-100-mu-g mL-1). Cromakalim-relaxed aortic rings precontracted with 15 mM but riot 60 mM K+. However, HA-22, HA-23 and verapamil produced a greater relaxation in 60 mM than in 15 mM K+-induced contraction, The tonic contractions elicited by KCl (60 mM) and Bay K 8644 (10(-7)M) were also relaxed by the addition of HA-22 and HA-23. The phenylephrine concentration-response curves displayed antagonism by HA-22 and HA-23 (10-100-mu-g mL-1) in a non-competitive manner. The caffeine (10 mM)-induced contraction and cAMP or cGMP levels were not affected by HA-22 or HA-23. It is concluded that HA-22 and HA-23 relaxed the rat aorta by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated Ca2+ channels.
關聯:	AMERICAN JOURNAL OF NEURORADIOLOGY 13(5):1326-1329
显示于类别:	[台中附設醫院] 期刊論文

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