INTRACRANIAL FETUS-IN-FETU - CT DIAGNOSIS

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Title:	INTRACRANIAL FETUS-IN-FETU - CT DIAGNOSIS
Authors:	YANG, ST;LEOW, SW
Contributors:	附設醫院放射線部;YANG, ST, CHINA MED COLL HOSP,DEPT RADIOL,75 YUTE RD,TAICHUNG,TAIWAN
Date:	1992
Issue Date:	2010-09-24 14:30:01 (UTC+8)
Publisher:	AMER SOC NEURORADIOLOGY
Abstract:	The pharmacological effects of HA-22 (2-(4'methoxyphenylmethyl)-3,4-dimethylpyrano[2,3-c] pyrazol-6(2H)-one) and HA-23 (2-(2'-thienylmethyl)-3,4-dimethylpyrano[2,3-c]pyrazol-6(2H)-one on rat isolated thoracic aorta have been examined. In high potassium medium (60 mM), Ca2+ (0.03-3 mM)-induced vasoconstriction was inhibited by HA-22 and HA-23 (10-100-mu-g mL-1). Cromakalim-relaxed aortic rings precontracted with 15 mM but riot 60 mM K+. However, HA-22, HA-23 and verapamil produced a greater relaxation in 60 mM than in 15 mM K+-induced contraction, The tonic contractions elicited by KCl (60 mM) and Bay K 8644 (10(-7)M) were also relaxed by the addition of HA-22 and HA-23. The phenylephrine concentration-response curves displayed antagonism by HA-22 and HA-23 (10-100-mu-g mL-1) in a non-competitive manner. The caffeine (10 mM)-induced contraction and cAMP or cGMP levels were not affected by HA-22 or HA-23. It is concluded that HA-22 and HA-23 relaxed the rat aorta by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated Ca2+ channels.
Relation:	AMERICAN JOURNAL OF NEURORADIOLOGY 13(5):1326-1329
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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