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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29199
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| 題名: | Haemolytic disease of the newborn due to maternal irregular antibodies in the Chinese population in Taiwan |
| 作者: | Wu, KH;Chu, SL;Chang, JG;Shih, MC;Peng, CT |
| 貢獻者: | 附設醫院兒科部;China Med Coll Hosp, Dept Pediat, Taichung 404, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:26:33 (UTC+8) |
| 出版者: | BLACKWELL PUBLISHING LTD |
| 摘要: | The purpose of this study was to investigate the antioxidant effects of a hot water extract of Panax notoginseng (PNG) against chronic ethanol-induced hepatotoxicity. Fifty mice were divided into five equal groups with 10 in each group. Group I (control) received saline, whereas group 2 received ethanol (70%, 0.1 mL, p.o.) once daily for 4 weeks, which induced hepatotoxicity, manifested biochemically by a significant elevation of serum enzyme activities, such as SGOT and SGPT. Hepatotoxicity was further evidenced by a significant increase in the hepatic lipid peroxidation measured. Groups 3-5 were administered a hot water extract of PNG at doses of 10, 25 and 50 mg/kg 2 weeks after initiating oral administration of ethanol, for a further 2 weeks. PNG ameliorated the rise in serum sGOT and sGPT induced by chronic ethanol administration. The mice were killed after PNG administration. In a separate study, PNG inhibited the lipid peroxidation in the mouse liver homogenate induced by ethanol in a dose-dependent manner. The findings indicate that PNG is an efficient cytoprotective agent against chronic ethanol-induced hepatotoxicity, possibly through inhibition of the production of oxygen-free radicals that cause lipid peroxidation. Copyright (C) 2003 John Wiley Sons, Ltd. |
| 關聯: | TRANSFUSION MEDICINE 13(5):311-314 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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