Haemolytic disease of the newborn due to maternal irregular antibodies in the Chinese population in Taiwan

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Title:	Haemolytic disease of the newborn due to maternal irregular antibodies in the Chinese population in Taiwan
Authors:	Wu, KH;Chu, SL;Chang, JG;Shih, MC;Peng, CT
Contributors:	附設醫院兒科部;China Med Coll Hosp, Dept Pediat, Taichung 404, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:26:33 (UTC+8)
Publisher:	BLACKWELL PUBLISHING LTD
Abstract:	The purpose of this study was to investigate the antioxidant effects of a hot water extract of Panax notoginseng (PNG) against chronic ethanol-induced hepatotoxicity. Fifty mice were divided into five equal groups with 10 in each group. Group I (control) received saline, whereas group 2 received ethanol (70%, 0.1 mL, p.o.) once daily for 4 weeks, which induced hepatotoxicity, manifested biochemically by a significant elevation of serum enzyme activities, such as SGOT and SGPT. Hepatotoxicity was further evidenced by a significant increase in the hepatic lipid peroxidation measured. Groups 3-5 were administered a hot water extract of PNG at doses of 10, 25 and 50 mg/kg 2 weeks after initiating oral administration of ethanol, for a further 2 weeks. PNG ameliorated the rise in serum sGOT and sGPT induced by chronic ethanol administration. The mice were killed after PNG administration. In a separate study, PNG inhibited the lipid peroxidation in the mouse liver homogenate induced by ethanol in a dose-dependent manner. The findings indicate that PNG is an efficient cytoprotective agent against chronic ethanol-induced hepatotoxicity, possibly through inhibition of the production of oxygen-free radicals that cause lipid peroxidation. Copyright (C) 2003 John Wiley Sons, Ltd.
Relation:	TRANSFUSION MEDICINE 13(5):311-314
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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