Longitudinal survey of fetal ventricular ejection and shortening fraction throughout pregnancy

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29179

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题名:	Longitudinal survey of fetal ventricular ejection and shortening fraction throughout pregnancy
作者:	Hsieh, YY;Chang, FCC;Tsai, HD;Tsai, CH
贡献者:	附設醫院兒科部;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat & Med, Taichung, Taiwan
日期:	2000
上传时间:	2010-09-24 14:25:37 (UTC+8)
出版者:	BLACKWELL SCIENCE LTD
摘要:	As part of our continuing search for potential anticancer candidates among 2-phenyl-4-quinolones and 2-phenyl-4-quinazolinones, two series of 6,7,2',3',4',5'-substituted 2-phenyl-4-quinazolinones and 6,2',3',4',5'-substituted 2,3-dihydro-2-phenyl-4-quinazolinones were synthesized and evaluated for cytotoxicity and as inhibitors of tubulin polymerization. In general, a good correlation was found between the two activities. Five of the 6-substituted heterocyclic 2-phenyl-4-quinozolinones (37-51) showed significant cytotoxicity against a panel of human tumor cell lines with EC50 values in the low micromolar to nanomolar concentration ranges. Compound 38 was the most potent of these compounds, as well as the most potent inhibitor of tubulin polymerization in this series. The activity of 38 was in the same range as those of the antimitotic natural products, colchicine, podophyllotoxin, and combretastatin A-4. Substituted 2-phenyl-4-quinazolinones and 2,3-dihydro-2-phenyl-4-quinazolinones also displayed highly selective cytotoxicity against the ovarian cancer 1A9 and P-gp resistant KB-VIN cell lines.
關聯:	ULTRASOUND IN OBSTETRICS & GYNECOLOGY 16(1):46-48
显示于类别:	[台中附設醫院] 期刊論文

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