Longitudinal survey of fetal ventricular ejection and shortening fraction throughout pregnancy

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Title:	Longitudinal survey of fetal ventricular ejection and shortening fraction throughout pregnancy
Authors:	Hsieh, YY;Chang, FCC;Tsai, HD;Tsai, CH
Contributors:	附設醫院兒科部;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat & Med, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:25:37 (UTC+8)
Publisher:	BLACKWELL SCIENCE LTD
Abstract:	As part of our continuing search for potential anticancer candidates among 2-phenyl-4-quinolones and 2-phenyl-4-quinazolinones, two series of 6,7,2',3',4',5'-substituted 2-phenyl-4-quinazolinones and 6,2',3',4',5'-substituted 2,3-dihydro-2-phenyl-4-quinazolinones were synthesized and evaluated for cytotoxicity and as inhibitors of tubulin polymerization. In general, a good correlation was found between the two activities. Five of the 6-substituted heterocyclic 2-phenyl-4-quinozolinones (37-51) showed significant cytotoxicity against a panel of human tumor cell lines with EC50 values in the low micromolar to nanomolar concentration ranges. Compound 38 was the most potent of these compounds, as well as the most potent inhibitor of tubulin polymerization in this series. The activity of 38 was in the same range as those of the antimitotic natural products, colchicine, podophyllotoxin, and combretastatin A-4. Substituted 2-phenyl-4-quinazolinones and 2,3-dihydro-2-phenyl-4-quinazolinones also displayed highly selective cytotoxicity against the ovarian cancer 1A9 and P-gp resistant KB-VIN cell lines.
Relation:	ULTRASOUND IN OBSTETRICS & GYNECOLOGY 16(1):46-48
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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