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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29016
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| 題名: | Prediction of survival in surgical unresectable lung cancer by artificial neural networks including genetic polymorphisms and clinical parameters |
| 作者: | Hsia, TC;Chiang, HC;Chiang, D;Hang, LW;Tsai, FJ;Chen, WC |
| 貢獻者: | 附設醫院內科部;China Med Coll Hosp, Dept Internal Med, Taichung, Taiwan;Natl Taiwan Univ, Dept Management, Taipei 10764, Taiwan;Ching Yun Inst Technol, Chungli, Taiwan;China Med Coll Hosp, Dept Med Genet, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung, Taiwan;China Med Coll Hosp, Dept Urol, Taichung, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:18:47 (UTC+8) |
| 出版者: | WILEY-LISS |
| 摘要: | Hypoxia and ischemia play important roles in the onset and progression of glaucoma. Insulin-like growth factors (IGF) are important neurotrophic agents that respond to hypoxia-ischemia. In this study, we enrolled 60 primary open angle glaucoma (POAG) patients and 104 healthy volunteers from the China Medical College Hospital. Among the polymorphism of IGFs gene, exon 9 Apa I C/T gene polymorphism is the most frequently seen. The polymorphism was observed following polymerase chain reaction based restriction analysis used to to resolve the relationship between IGF-II exon 9 Apa I C/T gene polymorphism and POAG. The distribution of the IGF-II exon 9 gene polymorphism showed statistical differences in the distribution of genotype frequencies between POAG patients and normal controls (P=0.010). The odds ratio of C/C homozygote was 0.266 (95% confidence interval=0.636-0.111). IGF-II is an important neurotrophic agent and regulates the suffering of POAG. C/C homozygote of IGF-II exon 9 Apa I C/T gene polymorphism is a useful marker of POAG in Chinese. (C) 2003 Wiley-Liss, Inc. |
| 關聯: | JOURNAL OF CLINICAL LABORATORY ANALYSIS 17(6):229-234 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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