Prediction of survival in surgical unresectable lung cancer by artificial neural networks including genetic polymorphisms and clinical parameters

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Title:	Prediction of survival in surgical unresectable lung cancer by artificial neural networks including genetic polymorphisms and clinical parameters
Authors:	Hsia, TC;Chiang, HC;Chiang, D;Hang, LW;Tsai, FJ;Chen, WC
Contributors:	附設醫院內科部;China Med Coll Hosp, Dept Internal Med, Taichung, Taiwan;Natl Taiwan Univ, Dept Management, Taipei 10764, Taiwan;Ching Yun Inst Technol, Chungli, Taiwan;China Med Coll Hosp, Dept Med Genet, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung, Taiwan;China Med Coll Hosp, Dept Urol, Taichung, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:18:47 (UTC+8)
Publisher:	WILEY-LISS
Abstract:	Hypoxia and ischemia play important roles in the onset and progression of glaucoma. Insulin-like growth factors (IGF) are important neurotrophic agents that respond to hypoxia-ischemia. In this study, we enrolled 60 primary open angle glaucoma (POAG) patients and 104 healthy volunteers from the China Medical College Hospital. Among the polymorphism of IGFs gene, exon 9 Apa I C/T gene polymorphism is the most frequently seen. The polymorphism was observed following polymerase chain reaction based restriction analysis used to to resolve the relationship between IGF-II exon 9 Apa I C/T gene polymorphism and POAG. The distribution of the IGF-II exon 9 gene polymorphism showed statistical differences in the distribution of genotype frequencies between POAG patients and normal controls (P=0.010). The odds ratio of C/C homozygote was 0.266 (95% confidence interval=0.636-0.111). IGF-II is an important neurotrophic agent and regulates the suffering of POAG. C/C homozygote of IGF-II exon 9 Apa I C/T gene polymorphism is a useful marker of POAG in Chinese. (C) 2003 Wiley-Liss, Inc.
Relation:	JOURNAL OF CLINICAL LABORATORY ANALYSIS 17(6):229-234
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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