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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/28880
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| 題名: | Spatial analysis of Yersinia pestis and Bartonella vinsonii subsp berkhoffii seroprevalence in California coyotes (Canis latrans) |
| 作者: | Hoar, BR;Chomel, BB;Rolfe, DL;Chang, CC;Fritz, CL;Sacks, BN;Carpenter, TE |
| 貢獻者: | 公共衛生學院環醫所;Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA;Univ Calif Davis, Wildlife Genet Sect, Vet Genet Lab, Davis, CA 95616 USA;Calif Dept Hlth Serv, Div Communicable Dis Control, Sacramento, CA USA;China Med Coll, Grad Inst Environm Hlth, Dept Publ Hlth, Taichung, Taiwan;Calif Dept Food & Agr, Anim Hlth Branch, Modesto, CA 95358 USA;Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 13:59:09 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE BV |
| 摘要: | The protective activity of melanin derived from tea (MDFT) was studied using hydrazine as a DNA-reactive chemical agent. Intra-peritoneal administration of MDFT at the doses of 5 or 20 mg/kg dose-dependently prevented liver toxicity induced by hydrazine in rats. It normalized rises in serum alanine transferase activity and a decrease in the glutathione level in the liver. It also reduced the hepatic malondialdehyde concentration. Monitoring the intensity of chemiluminescence showed that MDFT could prevent the production of free radicals that are generated owing to metabolic transformation of hydrazine. It also prevented the formation 8-hydroxy-deoxyguanosine (8-OH-dG) DNA adducts. The results obtained in vivo and in vitro suggest that MDFT confers marked protection of the liver against hydrazine-induced oxidative toxicity. (C) 2002 Elsevier Science Inc. All rights reserved. |
| 關聯: | PREVENTIVE VETERINARY MEDICINE 56(4):299-311 |
| 顯示於類別: | [環境醫學研究所(已停用)] 期刊論文
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