Estimates of cancer risk from chloroform exposure during showering in Taiwan

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 公共衛生學院 > 環境醫學研究所(已停用) > 期刊論文 > Item 310903500/28849

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题名:	Estimates of cancer risk from chloroform exposure during showering in Taiwan
作者:	Kuo, HW;Chiang, TF;Lo, II;Lai, JS;Chan, CC;Wang, JD
贡献者:	公共衛生學院環醫所;China Med Coll, Inst Environm Hlth, Taichung, Taiwan;Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan
日期:	1998
上传时间:	2010-09-24 13:58:03 (UTC+8)
出版者:	ELSEVIER SCIENCE BV
摘要:	Arylamine N-acetyltransferase (NAT) activities with 2-aminofluorene (2-AF) and p-aminobenzoic acid (PABA) as substrates were determined in Helicobacter pylori, collected from patients with peptic ulcers. The NAT activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. Inhibition of growth studies from H. pylori demonstrated that glycyrrhizic acid elicited dose-dependent bactericidal effect in H, pylori cultures, i.e.; the greater the concentration of glycyrrhizic acid, the greater the inhibition of growth of H. pylori. Cytosols or suspensions of H. pylori with and without selected concentrations of glycyrrhizic acid cotreatment showed different percentages of 2-AF and PABA acetylation. The data indicated that there was decreased NAT activity associated with increased glycyrrhizic acid in H. pylori cytosols and intact cells. For the cytosol and intact bacteria examinations, the apparent values of Km and Vmax were decreased after co-treated with 80 M glycyrrhizic acid. This report is the first demonstration of glycyrrhizic acid inhibition of arylamine NAT activity and glycyrrhizic acid inhibition of growth in the bacterium H. pylori.
關聯:	SCIENCE OF THE TOTAL ENVIRONMENT 218(1):1-7
显示于类别:	[環境醫學研究所(已停用)] 期刊論文

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