Estimates of cancer risk from chloroform exposure during showering in Taiwan

CMUR > College of Public Health > Graduate Institute of Environmental Medicine > Journal articles > Item 310903500/28849

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Title:	Estimates of cancer risk from chloroform exposure during showering in Taiwan
Authors:	Kuo, HW;Chiang, TF;Lo, II;Lai, JS;Chan, CC;Wang, JD
Contributors:	公共衛生學院環醫所;China Med Coll, Inst Environm Hlth, Taichung, Taiwan;Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan
Date:	1998
Issue Date:	2010-09-24 13:58:03 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	Arylamine N-acetyltransferase (NAT) activities with 2-aminofluorene (2-AF) and p-aminobenzoic acid (PABA) as substrates were determined in Helicobacter pylori, collected from patients with peptic ulcers. The NAT activity was determined using an acetyl CoA recycling assay and high pressure liquid chromatography. Inhibition of growth studies from H. pylori demonstrated that glycyrrhizic acid elicited dose-dependent bactericidal effect in H, pylori cultures, i.e.; the greater the concentration of glycyrrhizic acid, the greater the inhibition of growth of H. pylori. Cytosols or suspensions of H. pylori with and without selected concentrations of glycyrrhizic acid cotreatment showed different percentages of 2-AF and PABA acetylation. The data indicated that there was decreased NAT activity associated with increased glycyrrhizic acid in H. pylori cytosols and intact cells. For the cytosol and intact bacteria examinations, the apparent values of Km and Vmax were decreased after co-treated with 80 M glycyrrhizic acid. This report is the first demonstration of glycyrrhizic acid inhibition of arylamine NAT activity and glycyrrhizic acid inhibition of growth in the bacterium H. pylori.
Relation:	SCIENCE OF THE TOTAL ENVIRONMENT 218(1):1-7
Appears in Collections:	[Graduate Institute of Environmental Medicine] Journal articles

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