Adverse effect of air pollution on respiratory health of primary school children in Taiwan

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 公共衛生學院 > 環境醫學研究所(已停用) > 期刊論文 > Item 310903500/28848

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题名:	Adverse effect of air pollution on respiratory health of primary school children in Taiwan
作者:	Chen, PC;Lai, YM;Wang, JD;Yang, CY;Hwang, JS;Kuo, HW;Huang, SL;Chan, CC
贡献者:	公共衛生學院環醫所;Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan;Kaohsiung Med Coll, Sch Publ Hlth, Kaohsiung, Taiwan;Acad Sinica, Inst Stat Sci, Taipei 11529, Taiwan;China Med Coll, Inst Environm Hlth, Taichung, Taiwan;Natl Yang Ming Univ, Dept Social Med, Inst Publ Hlth, Taipei 112, Taiwan
日期:	1998
上传时间:	2010-09-24 13:58:02 (UTC+8)
出版者:	US DEPT HEALTH HUMAN SERVICES PUBLIC HEALTH SERVICE
摘要:	We examined the mechanisms of norathyriol on the serotonin-induced increased permeability of rat heart endothelial cell monolayers. The present study showed that the activation of rat heart endothelial cell protein kinase C by phorbol myristate acetate led to the dose-dependent increase in endothelial permeability to albumin, an effect that was inhibited by staurosporine (a protein kinase inhibitor). Staurosporine also attenuated the serotonin-induced increase in permeability. Norathyriol abolished both serotonin- and phorbol myristate acetate-induced permeability. We investigated whether norathyriol, by inhibiting protein kinase C activation, attenuated the serotonin-induced permeability. Immunofluorescence studies demonstrated that norathyriol prevented the redistribution of protein kinase C isozymes following stimulation with serotonin, Western blot analysis showed that norathyriol significantly inhibited the serotonin-induced translocation of the a protein kinase C isozyme from the cytosolic to the particulate fraction. In conclusion, norathyriol attenuates the serotonin-induced permeability of rat heart endothelial cells to macromolecules in association with inhibition of protein kinase C activation. This decrease in endothelial cell permeability may be one of the mechanisms for the protective effects of norathyriol against edema formation in response to inflammatory agonists in vivo. (C) 1998 Elsevier Science B.V. All rights reserved.
關聯:	ENVIRONMENTAL HEALTH PERSPECTIVES 106(6):331-335
显示于类别:	[環境醫學研究所(已停用)] 期刊論文

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