Adverse effect of air pollution on respiratory health of primary school children in Taiwan

CMUR > College of Public Health > Graduate Institute of Environmental Medicine > Journal articles > Item 310903500/28848

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/28848

Title:	Adverse effect of air pollution on respiratory health of primary school children in Taiwan
Authors:	Chen, PC;Lai, YM;Wang, JD;Yang, CY;Hwang, JS;Kuo, HW;Huang, SL;Chan, CC
Contributors:	公共衛生學院環醫所;Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan;Kaohsiung Med Coll, Sch Publ Hlth, Kaohsiung, Taiwan;Acad Sinica, Inst Stat Sci, Taipei 11529, Taiwan;China Med Coll, Inst Environm Hlth, Taichung, Taiwan;Natl Yang Ming Univ, Dept Social Med, Inst Publ Hlth, Taipei 112, Taiwan
Date:	1998
Issue Date:	2010-09-24 13:58:02 (UTC+8)
Publisher:	US DEPT HEALTH HUMAN SERVICES PUBLIC HEALTH SERVICE
Abstract:	We examined the mechanisms of norathyriol on the serotonin-induced increased permeability of rat heart endothelial cell monolayers. The present study showed that the activation of rat heart endothelial cell protein kinase C by phorbol myristate acetate led to the dose-dependent increase in endothelial permeability to albumin, an effect that was inhibited by staurosporine (a protein kinase inhibitor). Staurosporine also attenuated the serotonin-induced increase in permeability. Norathyriol abolished both serotonin- and phorbol myristate acetate-induced permeability. We investigated whether norathyriol, by inhibiting protein kinase C activation, attenuated the serotonin-induced permeability. Immunofluorescence studies demonstrated that norathyriol prevented the redistribution of protein kinase C isozymes following stimulation with serotonin, Western blot analysis showed that norathyriol significantly inhibited the serotonin-induced translocation of the a protein kinase C isozyme from the cytosolic to the particulate fraction. In conclusion, norathyriol attenuates the serotonin-induced permeability of rat heart endothelial cells to macromolecules in association with inhibition of protein kinase C activation. This decrease in endothelial cell permeability may be one of the mechanisms for the protective effects of norathyriol against edema formation in response to inflammatory agonists in vivo. (C) 1998 Elsevier Science B.V. All rights reserved.
Relation:	ENVIRONMENTAL HEALTH PERSPECTIVES 106(6):331-335
Appears in Collections:	[Graduate Institute of Environmental Medicine] Journal articles

Files in This Item:

There are no files associated with this item.

Loading...