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http://ir.cmu.edu.tw/ir/handle/310903500/28826
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| 題名: | Characteristics of road dust from different sampling sites in northern Taiwan |
| 作者: | Wang, CF;Chang, CY;Tsai, SF;Chiang, HL |
| 貢獻者: | 公共衛生學院風險管理系;Natl Tsing Hua Univ, Dept Nucl Sci, Hsinchu, Taiwan;China Med Univ, Dept Risk Management, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 13:56:28 (UTC+8) |
| 出版者: | AIR & WASTE MANAGEMENT ASSOC |
| 摘要: | Acute neuroprotective effects of cinnamophilin (CINN; (8R, 8'S)-4, 4'-dihydroxy-3, 3'-dimethoxy-7-oxo-8, 8'-neolignan), a novel antioxidant and free radical scavenger, were studied in a mouse model of transient middle cerebral artery (MCA) occlusion. CINN was administered intraperitoneally either 15 min before (pretreatment) or 2 h after the onset of MCA occlusion (postischemic treatment). Relative to vehicle-treated controls, animals pretreated with CINN, at 20-80 mg/kg, had significant reductions in brain infarction by 33-46% and improvements in neurobehavioral outcome. Postischemic administration with CINN (80 mg/kg) also significantly reduced brain infarction by 43% and ameliorated neurobehavioral deficits. Additionally, CINN administration significantly attenuated in situ accumulation of superoxide anions (02) in the boundary zones of infarct at 4 h after reperfusion. Consequently, CINN-treated animals exhibited significantly decreased levels of oxidative damage, as assessed by immunopositive reactions for 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 4-hydroxynonenal (4-HNE), and the resultant inflammatory reactions at 24 h postinsult. It is concluded that CINN effectively reduced brain infarction and improved neurobehavioral outcome following a short-term recovery period after severe transient focal cerebral ischemia in mice. The finding of a decreased extent of reactive oxygen species and oxidative damage observed with CINN treatment highlights that its antioxidant and radical scavenging ability is contributory. (c) 2005 Elsevier Inc. All rights reserved. |
| 關聯: | JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION 55(8):1236-1244 |
| 顯示於類別: | [健康風險管理學系] 期刊論文
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