Characteristics of road dust from different sampling sites in northern Taiwan

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 公共衛生學院 > 健康風險管理學系 > 期刊論文 > Item 310903500/28826

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/28826

题名:	Characteristics of road dust from different sampling sites in northern Taiwan
作者:	Wang, CF;Chang, CY;Tsai, SF;Chiang, HL
贡献者:	公共衛生學院風險管理系;Natl Tsing Hua Univ, Dept Nucl Sci, Hsinchu, Taiwan;China Med Univ, Dept Risk Management, Taichung, Taiwan
日期:	2005
上传时间:	2010-09-24 13:56:28 (UTC+8)
出版者:	AIR & WASTE MANAGEMENT ASSOC
摘要:	Acute neuroprotective effects of cinnamophilin (CINN; (8R, 8'S)-4, 4'-dihydroxy-3, 3'-dimethoxy-7-oxo-8, 8'-neolignan), a novel antioxidant and free radical scavenger, were studied in a mouse model of transient middle cerebral artery (MCA) occlusion. CINN was administered intraperitoneally either 15 min before (pretreatment) or 2 h after the onset of MCA occlusion (postischemic treatment). Relative to vehicle-treated controls, animals pretreated with CINN, at 20-80 mg/kg, had significant reductions in brain infarction by 33-46% and improvements in neurobehavioral outcome. Postischemic administration with CINN (80 mg/kg) also significantly reduced brain infarction by 43% and ameliorated neurobehavioral deficits. Additionally, CINN administration significantly attenuated in situ accumulation of superoxide anions (02) in the boundary zones of infarct at 4 h after reperfusion. Consequently, CINN-treated animals exhibited significantly decreased levels of oxidative damage, as assessed by immunopositive reactions for 8-hydroxy-2'-deoxyguanosine (8-OHdG) and 4-hydroxynonenal (4-HNE), and the resultant inflammatory reactions at 24 h postinsult. It is concluded that CINN effectively reduced brain infarction and improved neurobehavioral outcome following a short-term recovery period after severe transient focal cerebral ischemia in mice. The finding of a decreased extent of reactive oxygen species and oxidative damage observed with CINN treatment highlights that its antioxidant and radical scavenging ability is contributory. (c) 2005 Elsevier Inc. All rights reserved.
關聯:	JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION 55(8):1236-1244
显示于类别:	[健康風險管理學系] 期刊論文

文件中的档案:

没有与此文件相关的档案.

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....