資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/28645
|
| 題名: | Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2 ',3 ',4 '-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents |
| 作者: | Xia, Y;Yang, ZY;Xia, P;Bastow, KF;Tachibana, Y;Kuo, SC;Hamel, E;Hackl, T;Lee, KH |
| 貢獻者: | 中國醫藥大學;Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA;China Med Coll, Taichung, Taiwan;NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA |
| 日期: | 1998 |
| 上傳時間: | 2010-09-24 13:39:03 (UTC+8) |
| 出版者: | AMER CHEMICAL SOC |
| 摘要: | To determine the prevalence of hyperuricaemia, gout and gout-related factors in Central Taiwan Atayal aborigines, 342 subjects over 18 yr old were interviewed and examined. A questionnaire was designed to screen for signs and symptoms of gout and gout-related risk factors. Serum uric acid, triglyceride and creatinine were measured in all subjects. The prevalence of hyperuricaemia was 41.4% and that of gout 11.7% in aborigines. The uric acid level was 7.9 +/- 1.7 mg/dl in males and 5.7 +/- 1.5 in females, and differed significantly under age 70 yr (P < 0.001). Significantly increased triglyceride, creatinine and alcoholism was found in gouty patients compared with non-gouty patients. In 40 cases with gout, 54% had tophi and 35% of their first-degree relatives had gout. The high prevalence of hyperuricaemia and gout in Taiwan Atayal aborigines, a significant family predisposition, increased creatinine level and alcoholism suggest multiple factors affecting the hyperuricaemia. |
| 關聯: | JOURNAL OF MEDICINAL CHEMISTRY 41(7):1155-1162 |
| 顯示於類別: | [中國醫藥大學] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| jm9707479.pdf | | 226Kb | Adobe PDF | 597 | 檢視/開啟 |
|
在CMUR中所有的資料項目都受到原著作權保護.
|
