Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2 ',3 ',4 '-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents

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题名:	Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2 ',3 ',4 '-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents
作者:	Xia, Y;Yang, ZY;Xia, P;Bastow, KF;Tachibana, Y;Kuo, SC;Hamel, E;Hackl, T;Lee, KH
贡献者:	中國醫藥大學;Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA;China Med Coll, Taichung, Taiwan;NCI, Lab Drug Discovery Res & Dev, Dev Therapeut Program,Div Canc Treatment & Diag, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA
日期:	1998
上传时间:	2010-09-24 13:39:03 (UTC+8)
出版者:	AMER CHEMICAL SOC
摘要:	To determine the prevalence of hyperuricaemia, gout and gout-related factors in Central Taiwan Atayal aborigines, 342 subjects over 18 yr old were interviewed and examined. A questionnaire was designed to screen for signs and symptoms of gout and gout-related risk factors. Serum uric acid, triglyceride and creatinine were measured in all subjects. The prevalence of hyperuricaemia was 41.4% and that of gout 11.7% in aborigines. The uric acid level was 7.9 +/- 1.7 mg/dl in males and 5.7 +/- 1.5 in females, and differed significantly under age 70 yr (P < 0.001). Significantly increased triglyceride, creatinine and alcoholism was found in gouty patients compared with non-gouty patients. In 40 cases with gout, 54% had tophi and 35% of their first-degree relatives had gout. The high prevalence of hyperuricaemia and gout in Taiwan Atayal aborigines, a significant family predisposition, increased creatinine level and alcoholism suggest multiple factors affecting the hyperuricaemia.
關聯:	JOURNAL OF MEDICINAL CHEMISTRY 41(7):1155-1162
显示于类别:	[中國醫藥大學] 期刊論文

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