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請使用永久網址來引用或連結此文件:
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| 題名: | Tissue polypeptide specific antigen for early prediction of non-small cell lung cancer recurrence |
| 作者: | Chen, CY;Kao, CH;Hsieh, YH;Gu, CJ |
| 貢獻者: | 中國醫藥大學;TAICHUNG VET GEN HOSP,DEPT NUCL MED,TAICHUNG 40705,TAIWAN;TAICHUNG VET GEN HOSP,DIV THORAC SURG,TAICHUNG 40705,TAIWAN;CHUNG SHAN MED COLL,TAICHUNG 40705,TAIWAN;CHINA MED COLL,TAICHUNG 40705,TAIWAN |
| 日期: | 1997 |
| 上傳時間: | 2010-09-24 13:38:54 (UTC+8) |
| 出版者: | INT JOURNAL ONCOLOGY |
| 摘要: | We investigated the effects of type of dietary fat and phenobarbital an gamma-glutamyl transpeptidase-positive foci development. Four groups of six-female Sprague-Dawley rats were initiated with diethylnitrosamine (15 mg/kg) at 24 hours of age. After weaning, they were fed nutritionally complete semipurified diets containing 15% corn oil or 5% corn oil + 10% fish oil and supplemented with 5,000 ppm vitamin E with or without phenobarbital (500 ppm) for three months. Dietary fish oil significantly increased hepatic phospholipid eicosapentaenoate and docosahexaenoate concentrations and decreased arachidonate concentration compared with 15% corn oil (p < 0.05). Corn oil (15%) significantly increased-hepatic prostaglandin F-2 alpha concentration compared with 10% fish oil (p < 0.05). Phenobarbital significantly stimulated glutathione S-transferase activity in both dietary fat groups (p < 0.05). In the absence of phenobarbital, type of dietary far showed no effect on hepatic gamma-glutamyl transpeptidase-positive foci development. However, in the presence of phenobarbital, 15% corn oil significantly enhanced gamma-glutamyl transpeptidase-positive foci development compared with 10% fish oil (p < 0.05). Phenobarbital showed a strong tumor-promoting action in both dietary groups. In conclusion, there was an interaction between type of dietary fat and phenobarbital on gamma-glutamyl transpeptidase-positive foci development during hepatocarcinogenesis in rats. |
| 關聯: | ONCOLOGY REPORTS 4(6):1391-1394 |
| 顯示於類別: | [中國醫藥大學] 期刊論文
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