Tissue polypeptide specific antigen for early prediction of non-small cell lung cancer recurrence

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中國醫藥大學 > 期刊論文 > Item 310903500/28640

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题名:	Tissue polypeptide specific antigen for early prediction of non-small cell lung cancer recurrence
作者:	Chen, CY;Kao, CH;Hsieh, YH;Gu, CJ
贡献者:	中國醫藥大學;TAICHUNG VET GEN HOSP,DEPT NUCL MED,TAICHUNG 40705,TAIWAN;TAICHUNG VET GEN HOSP,DIV THORAC SURG,TAICHUNG 40705,TAIWAN;CHUNG SHAN MED COLL,TAICHUNG 40705,TAIWAN;CHINA MED COLL,TAICHUNG 40705,TAIWAN
日期:	1997
上传时间:	2010-09-24 13:38:54 (UTC+8)
出版者:	INT JOURNAL ONCOLOGY
摘要:	We investigated the effects of type of dietary fat and phenobarbital an gamma-glutamyl transpeptidase-positive foci development. Four groups of six-female Sprague-Dawley rats were initiated with diethylnitrosamine (15 mg/kg) at 24 hours of age. After weaning, they were fed nutritionally complete semipurified diets containing 15% corn oil or 5% corn oil + 10% fish oil and supplemented with 5,000 ppm vitamin E with or without phenobarbital (500 ppm) for three months. Dietary fish oil significantly increased hepatic phospholipid eicosapentaenoate and docosahexaenoate concentrations and decreased arachidonate concentration compared with 15% corn oil (p < 0.05). Corn oil (15%) significantly increased-hepatic prostaglandin F-2 alpha concentration compared with 10% fish oil (p < 0.05). Phenobarbital significantly stimulated glutathione S-transferase activity in both dietary fat groups (p < 0.05). In the absence of phenobarbital, type of dietary far showed no effect on hepatic gamma-glutamyl transpeptidase-positive foci development. However, in the presence of phenobarbital, 15% corn oil significantly enhanced gamma-glutamyl transpeptidase-positive foci development compared with 10% fish oil (p < 0.05). Phenobarbital showed a strong tumor-promoting action in both dietary groups. In conclusion, there was an interaction between type of dietary fat and phenobarbital on gamma-glutamyl transpeptidase-positive foci development during hepatocarcinogenesis in rats.
關聯:	ONCOLOGY REPORTS 4(6):1391-1394
显示于类别:	[中國醫藥大學] 期刊論文

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