Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 二年制呼吸治療學系 > 期刊論文 > Item 310903500/28347

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题名:	Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination
作者:	洪哲明(Che-Ming Hung);吳信志(Shinn-Chih Wu);顏至慶(Chih-Ching Yen);林明鋒(Ming-Fong Lin);賴怡 (Yi-Wen Lai);童鈺崇(Yu-Tang Tung);陳小玲(Hsiao-Ling Chen);陳全木(Chuan_Mu Chen)
贡献者:	健康照護學院二年制呼吸治療學系;中國附醫內科部胸腔科
关键词:	Porcine lactoferrin;Lymphocyte proliferation;Serum antibody titer;Cytokine;Infectious bursal disease (IBD);Vaccination
日期:	2010
上传时间:	2010-09-23 19:50:24 (UTC+8)
摘要:	In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-gamma and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.
關聯:	BIOMETALS 23(0):543-554
显示于类别:	[二年制呼吸治療學系] 期刊論文

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