Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination

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Title:	Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination
Authors:	洪哲明(Che-Ming Hung);吳信志(Shinn-Chih Wu);顏至慶(Chih-Ching Yen);林明鋒(Ming-Fong Lin);賴怡 (Yi-Wen Lai);童鈺崇(Yu-Tang Tung);陳小玲(Hsiao-Ling Chen);陳全木(Chuan_Mu Chen)
Contributors:	健康照護學院二年制呼吸治療學系;中國附醫內科部胸腔科
Keywords:	Porcine lactoferrin;Lymphocyte proliferation;Serum antibody titer;Cytokine;Infectious bursal disease (IBD);Vaccination
Date:	2010
Issue Date:	2010-09-23 19:50:24 (UTC+8)
Abstract:	In this study, recombinant porcine lactoferrin (PLF) was used as feedstuff additive to investigate the effects of peripheral lymphocyte proliferation and serum antibody titers in chickens vaccinated against the infectious bursal disease (IBD) virus. Treatment groups were fed three doses of PLF powder in their diet (0.5, 1.0, and 2.0% w/w), and the IBD vaccine was administrated at 1 and 3 weeks of age. At 8, 12, and 16 weeks after vaccination, serum IBD antibody titers were measured via the micro-method and T cell proliferation rates were evaluated. The results revealed that a high dose of PLF led to significant increases in serum IgA, IgG and IBD-specific antibody titers (P < 0.05). PLF administration, at either low or high doses, enhanced the expression of IFN-gamma and IL-12 in chicken T lymphocytes. These results suggest that PLF enhances cell-mediated immunity and augment the ability of IBD vaccination to strengthen subsequent anti-viral responses.
Relation:	BIOMETALS 23(0):543-554
Appears in Collections:	[Department of Respiratory Therapy] Journal articles

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