Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3, and tumor necrosis factor alpha -308 promoter: Non-association with endometriosis

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中醫學系暨碩博班 > 期刊論文 > Item 310903500/2794

請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/2794

題名:	Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3, and tumor necrosis factor alpha -308 promoter: Non-association with endometriosis
作者:	謝耀元;張其真(Chang CC);蔡輔仁(Fuu-Jen Tsai)*;(Hsu Y);蔡鴻德(Tsai HD);蔡長海(Chang-Hai Tsai)
貢獻者:	中醫學院中醫學系學士班中醫內科學科
關鍵詞:	endometriosis;interleukin-4;IL-4;polymorphism;tumor necrosis factor alpha;TNF-alpha
日期:	2002
上傳時間:	2009-08-20 17:56:42 (UTC+8)
摘要:	Interleukin-4 (IL-4) is a cytokine with anti-inflammatory properties. Tumor necrosis factor alpha (TNF-), a pluripotent proinflammatory cytokine, plays an important role in the process of numerous inflammatory and autoimmune diseases. We aimed to investigate whether gene polymorphisms for the IL-4 -590 promoter, IL-4 intron3 and TNF -308 promoter could be used as markers of susceptibility in endometriosis. The subjects, 226 premenopausal Taiwan Chinese women with surgically diagnosed endometriosis and nonendometriosis, were divided into two groups: 1) endometriosis (n = 120) and 2) nonendometriosis (n = 106). Polymorphisms for the IL-4 -590 promoter, IL-4 intron3, and TNF -308 G-to-A promoter were detected by polymerase chain reaction (PCR). Genotypes and allelic frequencies for these gene polymorphisms in both groups were compared. We observed no significant differences in genotype distribution and allele frequency of the IL-4 -590 promoter, IL-4 intron3, and TNF gene polymorphism between both groups. The proportions of the -590C homozygote/heterozygote/-590 T homozygote for the IL-4 promoter in both groups were 1.6/31.6/66.6% in group 1, and 5.8/33.0/61.2% in group 2. The proportions of the RP1 homozygote/heterozygote/RP2 homozygote for IL-4 intron3 in both groups were 62.5/34.1/2.5% (group 1), and 64.1/32.0/3.9% (group 2). The proportions of -308A homozygote/heterozygote/-308G homozygote for the TNF promoter in both groups were 7.5/20.8/71.7% (group 1), and 7.5/17/75.5% (group 2). We concluded that there is no association between endometriosis and the IL-4 and TNF gene polymorphisms. The IL-4 -590 promoter, IL-4 intron3, and TNF -308 G-to-A polymorphisms are not useful markers for predicting susceptibility to endometriosis. J. Clin. Lab. Anal. 16:121-126, 2002. © 2002 Wiley-Liss, Inc.
關聯:	JOURNAL OF CLINICAL LABORATORY ANALYSIS16(3):121~126
顯示於類別:	[中醫學系暨碩博班] 期刊論文

文件中的檔案:

檔案	大小	格式	瀏覽次數
	0Kb	Unknown	529	檢視/開啟

在CMUR中所有的資料項目都受到原著作權保護.

TAIR相關文章

資料載入中.....