Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3, and tumor necrosis factor alpha -308 promoter: Non-association with endometriosis

CMUR > College of Chinese Medicine > School of Chinese Medicine > Journal articles > Item 310903500/2794

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/2794

Title:	Polymorphisms for interleukin-4 (IL-4) -590 promoter, IL-4 intron3, and tumor necrosis factor alpha -308 promoter: Non-association with endometriosis
Authors:	謝耀元;張其真(Chang CC);蔡輔仁(Fuu-Jen Tsai)*;(Hsu Y);蔡鴻德(Tsai HD);蔡長海(Chang-Hai Tsai)
Contributors:	中醫學院中醫學系學士班中醫內科學科
Keywords:	endometriosis;interleukin-4;IL-4;polymorphism;tumor necrosis factor alpha;TNF-alpha
Date:	2002
Issue Date:	2009-08-20 17:56:42 (UTC+8)
Abstract:	Interleukin-4 (IL-4) is a cytokine with anti-inflammatory properties. Tumor necrosis factor alpha (TNF-), a pluripotent proinflammatory cytokine, plays an important role in the process of numerous inflammatory and autoimmune diseases. We aimed to investigate whether gene polymorphisms for the IL-4 -590 promoter, IL-4 intron3 and TNF -308 promoter could be used as markers of susceptibility in endometriosis. The subjects, 226 premenopausal Taiwan Chinese women with surgically diagnosed endometriosis and nonendometriosis, were divided into two groups: 1) endometriosis (n = 120) and 2) nonendometriosis (n = 106). Polymorphisms for the IL-4 -590 promoter, IL-4 intron3, and TNF -308 G-to-A promoter were detected by polymerase chain reaction (PCR). Genotypes and allelic frequencies for these gene polymorphisms in both groups were compared. We observed no significant differences in genotype distribution and allele frequency of the IL-4 -590 promoter, IL-4 intron3, and TNF gene polymorphism between both groups. The proportions of the -590C homozygote/heterozygote/-590 T homozygote for the IL-4 promoter in both groups were 1.6/31.6/66.6% in group 1, and 5.8/33.0/61.2% in group 2. The proportions of the RP1 homozygote/heterozygote/RP2 homozygote for IL-4 intron3 in both groups were 62.5/34.1/2.5% (group 1), and 64.1/32.0/3.9% (group 2). The proportions of -308A homozygote/heterozygote/-308G homozygote for the TNF promoter in both groups were 7.5/20.8/71.7% (group 1), and 7.5/17/75.5% (group 2). We concluded that there is no association between endometriosis and the IL-4 and TNF gene polymorphisms. The IL-4 -590 promoter, IL-4 intron3, and TNF -308 G-to-A polymorphisms are not useful markers for predicting susceptibility to endometriosis. J. Clin. Lab. Anal. 16:121-126, 2002. © 2002 Wiley-Liss, Inc.
Relation:	JOURNAL OF CLINICAL LABORATORY ANALYSIS16(3):121~126
Appears in Collections:	[School of Chinese Medicine] Journal articles

Files in This Item:

File	Size	Format
	0Kb	Unknown	529	View/Open

Loading...