Polymorphism for transforming growth factor beta 1-509 (TGF-B1-509): Association with endometriosis.

CMUR > College of Chinese Medicine > School of Chinese Medicine > Journal articles > Item 310903500/2759

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/2759

Title:	Polymorphism for transforming growth factor beta 1-509 (TGF-B1-509): Association with endometriosis.
Authors:	謝耀元;張其真(Chi-Chen Chang);蔡輔仁(Fuu-Jen Tsai)*;彭慶添(Ching-Tien Peng);葉聯舜(Lian-Shung Yeh);林正介(Cheng-Chieh Lin)
Contributors:	中醫學院中醫學系學士班中醫內科學科
Keywords:	cytokine;endometriosis;polymorphism;transforming growth factor
Date:	2005-06
Issue Date:	2009-08-20 17:56:27 (UTC+8)
Abstract:	Transforming growth factor beta (TGF-B) family members are multi-functional cytokines that play a key role in cellular growth, proliferation, and differentiation. The aim of the study was to investigate whether the TGF-B1-509 gene polymorphism could be used as a marker of susceptibility in endometriosis. Women were divided into two groups: endometriosis (n = 150) and non-endometriosis (n = 159). Polymorphisms for TGF-B1-509 genes were amplified by polymerase chain reaction and detected after restriction enzyme digestion. Genotypes and allelic frequencies in both groups were compared. Genotype proportions and allele frequencies of TGF-B1 gene polymorphisms differed significantly in both groups. Proportions of C homozygote, heterozygote, and T homozygote for TGF-B1 gene polymorphisms were 9.3/61.3/29.4% in the endometriosis group and 41.3/58.5/0% in the non-endometriosis group. Alleles C and T for TGF-B1 gene polymorphism were 40/60% (endometriosis) and 70.8/29.2% (non-endometriosis). Association of endometriosis with TGF-B1-509 gene polymorphism exists. T homozygote and T allele for TGF-B1 are associated with higher susceptibility to endometriosis.
Relation:	BIOCHEMICAL GENETICS 43(5-6):203~210
Appears in Collections:	[School of Chinese Medicine] Journal articles

Files in This Item:

File	Size	Format
	0Kb	Unknown	554	View/Open

Loading...