Polymorphism for transforming growth factor beta 1-509 (TGF-B1-509): Association with endometriosis.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中醫學系暨碩博班 > 期刊論文 > Item 310903500/2759

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題名:	Polymorphism for transforming growth factor beta 1-509 (TGF-B1-509): Association with endometriosis.
作者:	謝耀元;張其真(Chi-Chen Chang);蔡輔仁(Fuu-Jen Tsai)*;彭慶添(Ching-Tien Peng);葉聯舜(Lian-Shung Yeh);林正介(Cheng-Chieh Lin)
貢獻者:	中醫學院中醫學系學士班中醫內科學科
關鍵詞:	cytokine;endometriosis;polymorphism;transforming growth factor
日期:	2005-06
上傳時間:	2009-08-20 17:56:27 (UTC+8)
摘要:	Transforming growth factor beta (TGF-B) family members are multi-functional cytokines that play a key role in cellular growth, proliferation, and differentiation. The aim of the study was to investigate whether the TGF-B1-509 gene polymorphism could be used as a marker of susceptibility in endometriosis. Women were divided into two groups: endometriosis (n = 150) and non-endometriosis (n = 159). Polymorphisms for TGF-B1-509 genes were amplified by polymerase chain reaction and detected after restriction enzyme digestion. Genotypes and allelic frequencies in both groups were compared. Genotype proportions and allele frequencies of TGF-B1 gene polymorphisms differed significantly in both groups. Proportions of C homozygote, heterozygote, and T homozygote for TGF-B1 gene polymorphisms were 9.3/61.3/29.4% in the endometriosis group and 41.3/58.5/0% in the non-endometriosis group. Alleles C and T for TGF-B1 gene polymorphism were 40/60% (endometriosis) and 70.8/29.2% (non-endometriosis). Association of endometriosis with TGF-B1-509 gene polymorphism exists. T homozygote and T allele for TGF-B1 are associated with higher susceptibility to endometriosis.
關聯:	BIOCHEMICAL GENETICS 43(5-6):203~210
顯示於類別:	[中醫學系暨碩博班] 期刊論文

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