大葉千斤拔[Moghania macrophylla (Willd.) O. Ktze](=Flemingia congesta Robx.)為豆科(Leguminosae)蝶形花亞科(Papilionaceae)千斤拔屬(Moghania)植物,民間用於舒筋活絡、袪風止痛、散瘀消腫,治療風溼性關節炎及哮喘等疾病。主要分布於台灣及中國大陸南部各省。本研究室對於民間中草藥作一系列抗血小板凝集活性篩選實驗時,發現大葉千斤拔之根部甲醇粗抽取物具有明顯的抗血小板凝集活性。 另外,在抗發炎藥理實驗方面,發現大葉千斤拔之根部甲醇粗抽取物對大白鼠肥大細胞(Mast cell)所引起之組織胺釋放亦具有明顯的抑制作用。因此本研究計畫以上述生理活性為指標,進行活性物質之追蹤分離,純化其活性成分,以究明本植物之活性。
Moghania macrophylla (Willd.) O. Ktze (=Flemingia congesta Robx.) (Leguminosae) is a folk medicine which has been used for anti-inflammatory, rheumatism and anti-allergy in Taiwan and Southern China. In a preliminary bioassay, the methanolic extract of roots from the plant showed significant activity in antipatelet aggregation and antiinflammation activity in vitro assay. Therefore, we study the extractions, purifications and structure determinations of this plant to research its active principles.
