An Efficient One-Pot Synthesis of N-(1,3-Diphenyl-1H-Pyrazol-5-yl)amides

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Title:	An Efficient One-Pot Synthesis of N-(1,3-Diphenyl-1H-Pyrazol-5-yl)amides
Authors:	蘇威年(Su, W.-N.)、林宗平、鄭光閔(Cheng, K.-M.)、(ung, K.-C.)、(Lin, S.-K.)、翁豐富(Wong, Fung Fuh)*
Contributors:	藥學系
Date:	2010-07
Issue Date:	2010-08-24 10:14:32 (UTC+8)
Abstract:	A “one-pot” method for the synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides was developed by cyclization of benzoylacetonitrile (1) and phenylhydrazine in neat condition followed by acylation. The corresponding N-(1,3-diphenyl-1H-pyrazol-5-yl)amides were provided in good to excellent yields (70–90%). The significant advantages of the new synthetic method are excellent yields and simple work-up procedure without isolation and purification of intermediary 5-amino-1,3-diphenyl pyrazol (2). J. Heterocyclic Chem., (2010).
Relation:	JOURNAL OF HETEROCYCLIC CHEMISTRY 47(4):831~837
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Journal articles

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