In Chinese medicine, the patients？H？Hconstitutional types are classified according to their manifestation in disease circumstances, and different types of Chinese herbs are used to treat the patients by correcting the unbalanced status of body. In recent years, instead of the method of studying single gene, many molecular biological information and techniques provide very good methods to analyze the whole expression of the cell. The method to investigae the expression of large quantities of gene and the Chnese medical diagnostic method have similarity that they make use of the characteristics of individual for diagnosis. In this reaserch, we will use gene chips to study the the gene expression under the influence of the "hot" and "cold" Chinese herbs. The data will be analyzed by computer to find the "hot" and " cold" constitutinal related genes for advanced study. The results of this study will find out the molecular mechanism and control of the ？H？±cold？H？H and ？H？±hot？H？H constitutional types and to provide the molecular basis for the combination of Chinese and western medical diagnostic study.
