延續針對更強的細胞分化劑之研究中，選擇以AVLPR-OH為先導化合物做結構上的修飾。另一方面，由分子模擬設計一系列FIT-OH類緣化合物做為有絲分裂抑制劑。 標的化合物的合成以標準的固相peptide合成方法，針對peptide acids (TP-1, TP-3~TP-11及PP-1)之合成用Fmoc-Amino acid-Wang resin，而對於peptide amides (TP-2, PP-2及PP-3)之合成用Rink resin；合成之產物由逆相-高效液相層析法純化，繼而分子量由FAB-MS確認。; As part of our continuing search for potential cell differentiation agents, AVLPR-OH was selected as the lead compound for structural modification. On the other hand, a series of FIT-OH analogs was designed as antimitotic agents by Molecular Modeling. The target compounds were synthesized on Fmoc-Amino acid-Wang resin for peptide acids (TP-1, TP-3 — TP-11 and PP-1), and Rink resin for peptide amides (TP-2, PP-2 and PP- 3), by standard Solid Phase Peptide Synthesis. Each of synthesized products were purified by RP-HPLC and their molecular weight were confirmed by FAB-MS.
