合成FIT-OH及AVLPR-OH類緣化合物作為細胞分化劑與有絲分裂抑制劑; Synthesis of FIT-OH and AVLPR-OH analogs as cell differentiation agents and antimitotic agents

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥物化學研究所 > 博碩士論文 > Item 310903500/24095

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题名:	合成FIT-OH及AVLPR-OH類緣化合物作為細胞分化劑與有絲分裂抑制劑;Synthesis of FIT-OH and AVLPR-OH analogs as cell differentiation agents and antimitotic agents
作者:	劉玉晴;Yu-Ching Liu
贡献者:	中國醫藥學院藥物化學研究所
关键词:	細胞分化劑;有絲分裂抑制劑;固相peptide合成;分子模擬;cell differentiation agents;antimitotic agents;Solid Phase Peptide Synthesis;Molecular Modeling
日期:	1990
上传时间:	2009-12-03 09:29:39 (UTC+8)
摘要:	延續針對更強的細胞分化劑之研究中，選擇以AVLPR-OH為先導化合物做結構上的修飾。另一方面，由分子模擬設計一系列FIT-OH類緣化合物做為有絲分裂抑制劑。標的化合物的合成以標準的固相peptide合成方法，針對peptide acids (TP-1, TP-3~TP-11及PP-1)之合成用Fmoc-Amino acid-Wang resin，而對於peptide amides (TP-2, PP-2及PP-3)之合成用Rink resin；合成之產物由逆相-高效液相層析法純化，繼而分子量由FAB-MS確認。; As part of our continuing search for potential cell differentiation agents, AVLPR-OH was selected as the lead compound for structural modification. On the other hand, a series of FIT-OH analogs was designed as antimitotic agents by Molecular Modeling. The target compounds were synthesized on Fmoc-Amino acid-Wang resin for peptide acids (TP-1, TP-3 — TP-11 and PP-1), and Rink resin for peptide amides (TP-2, PP-2 and PP- 3), by standard Solid Phase Peptide Synthesis. Each of synthesized products were purified by RP-HPLC and their molecular weight were confirmed by FAB-MS.
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