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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/23956


    Title: 歸脾湯對去卵巢母鼠引起氧化應力的影響;Effect of Gui-Pi-Tang on oxidative stress induced by ovariectomy in female rats
    Authors: 余姿瑩;Tz-Ying Yu
    Contributors: 中國醫藥學院中國藥學研究所
    Keywords: 歸脾湯;去卵巢;氧化應力;Gui-Pi-Tang;ovariectomy;oxidative stress
    Date: 1990
    Issue Date: 2009-12-02 11:53:08 (UTC+8)
    Abstract: 母鼠雙側卵巢切除後會使腦部脂質過氧化程度上升，投予17?-estradiol可消除此上升作用，這些證實雌激素具有抗氧化作用。我們探討中藥方劑歸脾湯對去卵巢大鼠誘發腦部脂質過氧化的影響。去卵巢大鼠餵食含歸脾湯1 %、3%或5 % 的飼料12週。歸脾湯有意義減少去卵巢大鼠大腦皮質、紋狀體和海馬迴不加鐵誘發和加鐵誘發的脂質過氧化值，對加鐵與不加鐵誘發脂質過氧化差值也有抑制作用。以生體活性氧如超氧陰離子、氫氧自由基和歸脾湯作用來評估其抗氧化性質。歸脾湯對超氧陰離子清除能力不佳，但可以很快和氫氧自由基作用，其二次反應常數為1.10 *10 10 / M / sec。由這些結果推測歸脾湯對去卵巢大鼠腦部氧化傷害的保護作用與其清除自由基的能力有關。; The increase in the lipid peroxidation (LPO) level in the brain of female rats after bilateral ovariectomy, and this increase was abolished upon administration of 17?-estradiol. These results evidenced that estrogen present antioxidant activity in brain of female rats. We examined the effects of Gui-Pi-Tang (GPT), a traditional Chinese medicine, on increased LPO level in the brain of ovariectomized (OVX) rats. Ovariectomized rats were provided with a diet containing 1 %, 3 % or 5 % GPT for 12 weeks. GPT significantly decreased 1) the contents of Fe-independent and Fe-dependent LPO concentrations in cerebral cortex, striatum and hippocampus in OVX rats; 2) the differences between Fe-stimulated level of LPO and the basal level in same examined tissues.The antioxidant properties of GPT were also evaluated by studying the ability of this drug to reactive with relevant biological oxidants such as superoxide anion radical and hydroxyl radical. GPT is not good scavenger of superoxide anion. However, it reacts rapidly with OH radical with a second-order rate constant 1.10 * 10 10 / M / sec. Our results suggested that the protection against oxidative damage by GPT in the OVX rat brain may be due to its scavenging activity against free radicals.
    Appears in Collections:[Graduate Institute of Chinese Pharmaceutical Science] Theses & dissertations

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    中文摘要.pdf12KbAdobe PDF561View/Open
    參考文獻 5.31new.pdf33KbAdobe PDF455View/Open
    圖目錄.pdf18KbAdobe PDF431View/Open
    封面.pdf10KbAdobe PDF493View/Open
    材料與方法new.pdf48KbAdobe PDF1828View/Open
    目錄.pdf10KbAdobe PDF484View/Open
    第一章 總論.pdf21KbAdobe PDF977View/Open
    第三章 歸脾湯對去卵巢大鼠氧化應力相關指標的影n.pdf44KbAdobe PDF948View/Open
    第三章所有的圖.pdf55KbAdobe PDF409View/Open
    第二章 136 OVX--Oxidative stress-3.pdf45KbAdobe PDF1148View/Open
    第二章所有的圖.pdf46KbAdobe PDF351View/Open
    第五章 歸脾湯對去卵巢大鼠誘發骨質疏鬆的影new.pdf30KbAdobe PDF960View/Open
    結論.pdf12KbAdobe PDF646View/Open
    英文摘要.pdf12KbAdobe PDF399View/Open
    表目錄.pdf15KbAdobe PDF447View/Open
    謝 辭.pdf20KbAdobe PDF659View/Open
    附 錄.pdf24KbAdobe PDF495View/Open
    附 錄_目錄_.pdf12KbAdobe PDF676View/Open
    骨的圖.pdf17KbAdobe PDF371View/Open


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