Synthesis and Anticancer Activity of 3, 6-Substituted 9-picolyl Carbazole Derivatives

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥物化學研究所 > 會議論文 > Item 310903500/22789

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题名:	Synthesis and Anticancer Activity of 3, 6-Substituted 9-picolyl Carbazole Derivatives
作者:	(Ya-Lin Huang(黃雅);(Chun-Ta Feng (馮);(Chun-Jen Chen(陳);(Chin-Wen Wang (王);郭盛助(Sheng-Chu Kuo);黃麗嬌(Li-Jiau Huang)*
贡献者:	藥學院藥物化學研究所
日期:	2004-03-05
上传时间:	2009-09-07 12:20:58 (UTC+8)
摘要:	In our laboratory, a series of 3,6-substituted-9-benzyl carbazole derivatives were synthesized, and we found that some of these carbazole derivatives showed significant cytotoxic effects on human leukemia cells. Following the previous results, a series of 3,6-substituted-9-picolyl carbazole derivatives was synthesized. Initially, reaction of carbazole (1) with appropriate picolyl chlorides yielded the corresponding compounds 9-(2-picolyl) carbazole (2), 9-(3-picolyl) carbazole (3) and 9-(4-picolyl) carbazole (4). Subsequently, compounds 1—4 underwent Vielsmeir formylation by treating with POCl3/DMF to give corresponding carboxaldehydes 1a—4a, and compounds 1—4 was to afford the corresponding 3-acetylated products 1b—4b. Among these compounds, 2b, 3b and 4b showed potential effective on A549 cells, 3b showed the most potential effect on HA22T cells. Furthermore, we found that compounds 2b, 3b and 4b had significant cell differentiating effect on HL-60 cells. These finding demonstrated that these novel synthesized compounds could be developed as novel anticancer agents.
關聯:	2004藥物化學研討會
显示于类别:	[藥物化學研究所] 會議論文

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