Synthesis and Anticancer Activity of 3, 6-Substituted 9-picolyl Carbazole Derivatives

CMUR > College of Pharmacy > Graduate Institute of Pharmaceutical Chemistry > Proceedings > Item 310903500/22789

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/22789

Title:	Synthesis and Anticancer Activity of 3, 6-Substituted 9-picolyl Carbazole Derivatives
Authors:	(Ya-Lin Huang(黃雅);(Chun-Ta Feng (馮);(Chun-Jen Chen(陳);(Chin-Wen Wang (王);郭盛助(Sheng-Chu Kuo);黃麗嬌(Li-Jiau Huang)*
Contributors:	藥學院藥物化學研究所
Date:	2004-03-05
Issue Date:	2009-09-07 12:20:58 (UTC+8)
Abstract:	In our laboratory, a series of 3,6-substituted-9-benzyl carbazole derivatives were synthesized, and we found that some of these carbazole derivatives showed significant cytotoxic effects on human leukemia cells. Following the previous results, a series of 3,6-substituted-9-picolyl carbazole derivatives was synthesized. Initially, reaction of carbazole (1) with appropriate picolyl chlorides yielded the corresponding compounds 9-(2-picolyl) carbazole (2), 9-(3-picolyl) carbazole (3) and 9-(4-picolyl) carbazole (4). Subsequently, compounds 1—4 underwent Vielsmeir formylation by treating with POCl3/DMF to give corresponding carboxaldehydes 1a—4a, and compounds 1—4 was to afford the corresponding 3-acetylated products 1b—4b. Among these compounds, 2b, 3b and 4b showed potential effective on A549 cells, 3b showed the most potential effect on HA22T cells. Furthermore, we found that compounds 2b, 3b and 4b had significant cell differentiating effect on HL-60 cells. These finding demonstrated that these novel synthesized compounds could be developed as novel anticancer agents.
Relation:	2004藥物化學研討會
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Proceedings

Files in This Item:

There are no files associated with this item.

Loading...