The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 中國藥學研究所(已停用) > 期刊論文 > Item 310903500/2113

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题名:	The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors.
作者:	謝明村(Hsieh,Ming-Tsuen)*;吳啟瑞(Wu,Chi-Rei);王文信;(林立偉)
贡献者:	藥學院中國藥學研究所
关键词:	Fructus Schisandra water layer;cycloheximide;passive avoidance task;rats
日期:	2001-01
上传时间:	2009-08-19 17:24:49 (UTC+8)
摘要:	Our previous study indicated that the water layer present in Fructus Schisandra(FSw) at 10 and 25 mg kg−1significantly counteracted cycloheximide (CXM)-induced amnesia. Therefore, the mechanism of action of the ameliorating effect of FSwon CXM-induced amnesia in the passive avoidance task was investigated in rats. The ameliorating effect of FSwon CXM-induced amnesia was depressed by scopolamine. The serotonin releaser, p -chloroamphetamine significantly antagonized the ameliorating effect of FSwon CXM-induced amnesia. Furthermore, the ameliorating effect was also inhibited by the 5-HT1Areceptor agonist 8-OH-DPAT, but potentiated by the 5-HT2receptor antagonist ritanserin. Finally, the GABAAreceptor antagonist bicuculline blocked the ameliorating effect of FSw. These results suggest that the beneficial effect of FSwon CXM-induced amnesia is amplified by treatment with serotonergic 5-HT2receptor antagonists, but reduced by serotonergic 5-HT1Areceptor agonists as well as GABAAand cholinergic receptor antagonists.
關聯:	PHARMACOLOGICAL RESEARCH43(1):17~22
显示于类别:	[中國藥學研究所(已停用)] 期刊論文

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