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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/2113


    Title: The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors.
    Authors: 謝明村(Hsieh,Ming-Tsuen)*;吳啟瑞(Wu,Chi-Rei);王文信;(林立偉)
    Contributors: 藥學院中國藥學研究所
    Keywords: Fructus Schisandra water layer;cycloheximide;passive avoidance task;rats
    Date: 2001-01
    Issue Date: 2009-08-19 17:24:49 (UTC+8)
    Abstract: Our previous study indicated that the water layer present in Fructus Schisandra(FSw) at 10 and 25 mg kg−1significantly counteracted cycloheximide (CXM)-induced amnesia. Therefore, the mechanism of action of the ameliorating effect of FSwon CXM-induced amnesia in the passive avoidance task was investigated in rats. The ameliorating effect of FSwon CXM-induced amnesia was depressed by scopolamine. The serotonin releaser, p -chloroamphetamine significantly antagonized the ameliorating effect of FSwon CXM-induced amnesia. Furthermore, the ameliorating effect was also inhibited by the 5-HT1Areceptor agonist 8-OH-DPAT, but potentiated by the 5-HT2receptor antagonist ritanserin. Finally, the GABAAreceptor antagonist bicuculline blocked the ameliorating effect of FSw. These results suggest that the beneficial effect of FSwon CXM-induced amnesia is amplified by treatment with serotonergic 5-HT2receptor antagonists, but reduced by serotonergic 5-HT1Areceptor agonists as well as GABAAand cholinergic receptor antagonists.
    Relation: PHARMACOLOGICAL RESEARCH43(1):17~22
    Appears in Collections:[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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