Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: Interactions with compounds acting at 5-HT1A and 5-HT2 receptors.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 中國藥學研究所(已停用) > 期刊論文 > Item 310903500/2092

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/2092

题名:	Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: Interactions with compounds acting at 5-HT1A and 5-HT2 receptors.
作者:	謝明村(Hsieh,Ming-Tsuen)*;吳啟瑞(Wu,Chi-Rei);謝佳璋
贡献者:	藥學院中國藥學研究所
关键词:	p-Hydroxybenzyl alcohol;Cycloheximide;Cholinergic receptor;Serotonergic receptor;Passive avoidance task;Piracetam
日期:	1998-08
上传时间:	2009-08-19 17:24:42 (UTC+8)
摘要:	The effect of p-hydroxybenzyl alcohol (HBA) on cycloheximide (CXM)-induced impairment in the step-through passive avoidance task was investigated in rats and compared to the effect of the nootropic piracetam. HBA and piracetam significantly counteracted the CXM-induced shortening of retention latencies. The effect of HBA was a bell-shaped dose–response curve with a maximal effect of 5 mg/kg. The counteractive effect of HBA was not depressed by either scopolamine or mecamylamine. The serotonin (5-HT) releaser, p-chloroamphetamine, and presursor, 5-hydroxytryptophan, significantly antagonized the counteractive effect of HBA on the CXM-induced shortening of retention latencies. Furthermore, the counteractive effect was also inhibited by the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the 5-HT2 receptor agoinst 1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane [(±)-DOI], but potentiated by the 5-HT1 receptor antagonist (±)-pindolol and the 5-HT2 receptor antagonist ritanserin. There results suggest that the beneficial effect of HBA on CXM-induced impairment is amplified by treatment with serotonergic receptor antagonists but reduced by serotonergic 5-HT1A and 5-HT2 receptor agonists, and insensitive to cholinergic manipulations.
關聯:	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR60(2):337~343
显示于类别:	[中國藥學研究所(已停用)] 期刊論文

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	805	检视/开启

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....