Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: Interactions with compounds acting at 5-HT1A and 5-HT2 receptors.

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Title:	Ameliorating effect of p-hydroxybenzyl alcohol on cycloheximide-induced impairment of passive avoidance response in rats: Interactions with compounds acting at 5-HT1A and 5-HT2 receptors.
Authors:	謝明村(Hsieh,Ming-Tsuen)*;吳啟瑞(Wu,Chi-Rei);謝佳璋
Contributors:	藥學院中國藥學研究所
Keywords:	p-Hydroxybenzyl alcohol;Cycloheximide;Cholinergic receptor;Serotonergic receptor;Passive avoidance task;Piracetam
Date:	1998-08
Issue Date:	2009-08-19 17:24:42 (UTC+8)
Abstract:	The effect of p-hydroxybenzyl alcohol (HBA) on cycloheximide (CXM)-induced impairment in the step-through passive avoidance task was investigated in rats and compared to the effect of the nootropic piracetam. HBA and piracetam significantly counteracted the CXM-induced shortening of retention latencies. The effect of HBA was a bell-shaped dose–response curve with a maximal effect of 5 mg/kg. The counteractive effect of HBA was not depressed by either scopolamine or mecamylamine. The serotonin (5-HT) releaser, p-chloroamphetamine, and presursor, 5-hydroxytryptophan, significantly antagonized the counteractive effect of HBA on the CXM-induced shortening of retention latencies. Furthermore, the counteractive effect was also inhibited by the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the 5-HT2 receptor agoinst 1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane [(±)-DOI], but potentiated by the 5-HT1 receptor antagonist (±)-pindolol and the 5-HT2 receptor antagonist ritanserin. There results suggest that the beneficial effect of HBA on CXM-induced impairment is amplified by treatment with serotonergic receptor antagonists but reduced by serotonergic 5-HT1A and 5-HT2 receptor agonists, and insensitive to cholinergic manipulations.
Relation:	PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR60(2):337~343
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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