Cardiovascular disease in one of the most important leading cause of death in Taiwan. The metabolic syndrome is strongly associated with insulin resistance and has been recognized as a cluster of risk factors for cardiovascular diseases such as visceral obesity, hypertension, diabetes and dyslipidemia. The metabolic syndrome is a multifactorial complex trait that is influenced by both environmental and genetic factors. Production of these proteins by adipose tissue is all most increased in obesity, and raised circulating levels of several acute-phase proteins and inflammatory cytokines has led to the view that the obese are characterized by a state of chronic low-grade inflammation, and that this links causally to insulin resistance and the metabolic syndrome. Serum adiponectin levels have been shown to be reduced in the presence of obesity, insulin resistance (IR), and cardiovascular disease. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene have been reported. Aims: The aims of this study are: 1. To under the prevalence of metabolic syndrome and its related factor. 2. To assess the correlation between metabolic syndrome and serum adiponectin level.3.To assess the genotype of SNP associated with reduced adiponectin level. These data will be a basis for further study in the Taiwan .On the basis of these data, more intervention to reduce metabolic syndrome related disease will be reasonable.
