代謝症候群與脂締素濃度及其基因變異之相關性

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學系 > 研究計畫 > Item 310903500/13030

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题名:	代謝症候群與脂締素濃度及其基因變異之相關性
其它题名:	Association of Adiponectin Level and Variants in the Adiponectin Gene in Metabolic Syndrome in Taiwan
作者:	劉秋松(Liu,Chiu-Shong);林正介(Lin,Cheng-Chieh);吳明蒼(Ming-Tsang Wu);林志學(Chih-Hsueh Lin);李采娟(Li,Tsai-Chung)
贡献者:	醫學院醫學系學士班家庭醫學科;中國附醫社區醫學部家庭醫學科
日期:	2007-07-31
上传时间:	2009-09-01 16:13:05 (UTC+8)
摘要:	本計畫首先建立本研究希望藉由一個隨機的社區性樣本，瞭解社區居民代謝症候群盛行情形，及其與脂締素濃度及單一核?酸多形性相關性，其研究目的為了解代謝症候群之盛行率及其危險因子，探討代謝症候群與脂締素濃度相關性，探討代謝症候群與脂締素基因多形性之相關性，本研究結果顯示低濃度脂締素會增加罹患代謝症候群的危險性，若具有越多代謝症候群指標異常者，其脂締素濃度會隨之下降。脂締素基因SNP276 及SNP-11377 的基因多型性與罹患代謝症候群並無顯著之相關性，且發現二個脂締素基因亦無交互作用關係。完全達成計畫書的目標。未來更多脂締素基因多型性與罹患代謝症候群間的關係宜再進一步探討。 Cardiovascular disease in one of the most important leading cause of death in Taiwan. The metabolic syndrome is strongly associated with insulin resistance and has been recognized as a cluster of risk factors for cardiovascular diseases such as visceral obesity, hypertension, diabetes and dyslipidemia. The metabolic syndrome is a multifactorial complex trait that is influenced by both environmental and genetic factors. Production of these proteins by adipose tissue is all most increased in obesity, and raised circulating levels of several acute-phase proteins and inflammatory cytokines has led to the view that the obese are characterized by a state of chronic low-grade inflammation, and that this links causally to insulin resistance and the metabolic syndrome. Serum adiponectin levels have been shown to be reduced in the presence of obesity, insulin resistance (IR), and cardiovascular disease. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene have been reported. Aims: The aims of this study are: 1. To under the prevalence of metabolic syndrome and its related factor. 2. To assess the correlation between metabolic syndrome and serum adiponectin level.3.To assess the genotype of SNP associated with reduced adiponectin level. These data will be a basis for further study in the Taiwan .On the basis of these data, more intervention to reduce metabolic syndrome related disease will be reasonable.
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