The majority of workers with a potential for skin contact by hazardous materials are protected by utilizing chemically resistant clothing or gloves. A large fraction of experimental work has been focus on the permeation of a chemical from a neat challenge liquid. Many of the liquids to which workers may be exposed, however, are mixture chemicals rather than single component in composition. At present there are no generally applicable correlations for predicting the permeation properties of mixture chemicals from the results of tests with single component liquids. Permeation of organic solvents mixtures was effect by their polarity, especially when the difference between the individual polarities was large, co-solvent effect 3 easily happened. And the bigger LogKow values of organic solvent, the earlier BT; the lower LogKow values of organic solvent, the longer BT. In the repeat used study, After using 70 @10H decontamination method, .degree.C for the long time and high temperature, the material of sample was seen to change end of the test was due to cumulative mass and JS increase gradually, and the exposure risk maybe raise. Results showed that JS of the washing decontamination methods was non-significant with the others; the 70.degree.C @2H, 40.degree.C @2H and 40.degree.C @10H decontamination method were significant statistically, P values were 0.019 and 0.008, and Js of 40.degree.C @10H decontamination method was decrease gradually; BT of the washing decontamination method was 24.03+-2.76 min was under then the others was 38.61+-5.58 min, P<0.001.